Benvenuto Cellini was born in Florence, Italy. His parents were Giovanni Cellini, and Maria Lisabetta Granacci. They were married for eighteen years before the birth of their first child. Benvenuto was the second child of the family. The son of a musician and builder of musical instruments, Cellini's first major brush with the law came as an early teenager: He was banished from his native Florence for his alleged role in a brawl. As a result, he received his early artistic training not only from the Florentine goldsmith Marcone [Antonio di Sandro], but also from Francesco Castoro, a goldsmith of Siena. After further visits to Bologna and Pisa, Cellini was allowed to return to Florence and continue his work there.







Giovanni initially wished Benvenuto to join him in instrument making, and endeavoured to thwart his inclination for metalwork. When he was fifteen, his father reluctantly agreed to apprentice him to a goldsmith, Antonio di Sandro, nicknamed Marcone. At the age of sixteen, Benvenuto had already attracted attention in Florence by taking part in an affray with youthful companions. He escaped punishment by fleeing for six months to Siena, where he worked for a goldsmith named Fracastoro (unrelated to the Veronese polymath). From Siena he moved to Bologna, where he became a more accomplished flute player and made progress as a goldsmith. After a visit to Pisa and two periods of living in Florence (where he was visited by the sculptor Torrigiano), he moved to Rome, age nineteen.[1]






[edit] Work in Rome


Perseus with the Head of MedusaHis first works in Rome were a silver casket, silver candlesticks, and a vase for the bishop of Salamanca, which won him the approval of Pope Clement VII. Another celebrated work from Rome is the gold medallion of "Leda and the Swan" executed for the Gonfaloniere Gabbriello Cesarino, and which is now in the Vienna museum. He also took up the flute again, and was appointed one of the pope's court musicians.






In the attack upon Rome by Charles III, Duke of Bourbon, Cellini's bravery proved of signal service to the pontiff. According to his own accounts, he himself shot and injured Philibert of Châlon, prince of Orange.[2] (Allegedly Cellini also killed Charles III, Duke of Bourbon during the Siege of Rome.) His bravery led to a reconciliation with the Florentine magistrates,[3] and he soon returned to his hometown. Here he devoted himself to crafting medals, the most famous of which are "Hercules and the Nemean Lion", in gold repoussé work, and "Atlas supporting the Sphere", in chased gold, the latter eventually falling into the possession of Francis I of France.






From Florence he went to the court of the duke of Mantua, and then again to Florence. On returning to Rome, he was employed in the working of jewellery and in the execution of dies for private medals and for the papal mint. In 1529 his brother Cecchino killed a Corporal of the Roman Watch and in turn was wounded by an arquebusier, later dying of his wound. Soon afterward Benvenuto killed his brother's killer – an act of blood revenge but not justice as Cellini admits that his brother's killer had acted in self-defense.[4] Cellini fled to Naples to shelter from the consequences of an affray with a notary, Ser Benedetto, whom he had wounded. Through the influence of several cardinals, Cellini obtained a pardon. He found favor with the new pope, Paul III, notwithstanding a fresh homicide during the interregnum three days after the death of Pope Clement VII in September 1534. The fourth victim was a rival goldsmith, Pompeo of Milan.[5]






[edit] Ferrara and France


Modern replica of a statue in the pedestal of Perseus; Loggia dei Lanzi, Florence, Italy. The original is on display at the Museo del Bargello in FlorenceThe plots of Pierluigi Farnese led to Cellini's retreat from Rome to Florence and Venice, where he was restored with greater honour than before. At the age of 37, upon returning from a visit to the French court, he was imprisoned on a charge (apparently false) of having embezzled during the war the gems of the pope's tiara. He was confined in the Castel Sant'Angelo, escaped, was recaptured, and treated with great severity, and was in daily expectation of death on the scaffold. The intercession of Pierluigi's wife, and especially that of the Cardinal d'Este of Ferrara, eventually secured Cellini's release, in gratitude for which he gave d'Este a splendid cup.[6]






Cellini then worked at the court of Francis I at Fontainebleau and Paris. However, he considered the duchesse d'Étampes to be set against him and refused to conciliate with the king's favorites. He could no longer silence his enemies by the sword, as he had silenced those in Rome. As a result, after about five years of invested work but continual jealousy and violence, Cellini returned to Florence, where he continued as a goldsmith and became the rival of sculptor Baccio Bandinelli[7] who died a few years later in 1560.






[edit] Death in FlorenceDuring the war with Siena, Cellini was appointed to strengthen the defences of his native city, and, though rather shabbily treated by his ducal patrons, he continued to gain the admiration of his fellow-citizens by the magnificent works which he produced. He was also named a member (Accademico) of the prestigious Accademia delle Arti del Disegno of Florence, founded by the Duke Cosimo I de' Medici, at 13 January 1563, under the influence of the architect Giorgio Vasari. He died in Florence in 1571 and was buried with great pomp in the church of the Santissima Annunziata. He had supported in Florence a widowed sister and her six daughters.






[edit] Personal relationships


Modern replica of the statue of Danaë in the pedestal of Perseus; Loggia dei Lanzi, Florence, Italy. The original is on display at the Museo del Bargello in Florence.Cellini is known to have taken some of his female models as mistresses, having an illegitimate daughter in 1544 with one of them while living in France, whom he named Costanza.[8] After briefly attempting a clerical career, in 1562, he married a servant, Piera Parigi, with whom he claimed he had five children, of which only a son and two daughters survived him.






Aside from his marriage, Cellini was officially accused or charged at least three times of the crime of sodomy with men, and on one occasion with a woman.






14 January 1523 he was sentenced to pay 12 staia of flour for relations with a boy named Domenico di ser Giuliano da Ripa.[9]


While in Paris, a former model and lover brought charges against him of using her "after the Italian fashion."( i.e. Sodomy) [9]


In Florence in 1548, Cellini was accused by a woman named Margherita, for having certain familiarities with her son, Vincenzo.[10]


26 February 1556, his apprentice Fernando di Giovanni di Montepulciano accused his mentor of having sodomised him many times.[11] This time the penalty was a hefty fifty golden scudi fine, and four years of prison, remitted to four years of house arrest thanks to the intercession of the Medicis.[9]


Towards the end of his life during a public altercation before Duke Cosimo, Bandinelli had called out to him Sta cheto, soddomitaccio! (Shut up, you filthy sodomite!) Cellini described this as an "atrocious insult."[12]






[edit] Artwork[edit] Statues


Perseus with the Head of Medusa in the Loggia dei Lanzi gallery on the edge of the Piazza della Signoria in Florence; picture taken after the statue's cleaning and restoration.Besides his works in gold and silver, Cellini executed sculptures of grander scale. The most distinguished of these is the bronze group of Perseus with the Head of Medusa, a work (first suggested by Duke Cosimo I de Medici) now in the Loggia dei Lanzi at Florence, his attempt to surpass Michelangelo's David and Donatello's Judith and Holofernes. The casting of this work caused Cellini much trouble and anxiety, but it was hailed as a masterpiece as soon as it was completed. The original relief from the foot of the pedestal—Perseus and Andromeda—is in the Bargello, and replaced by a cast.






By 1996, centuries of environmental pollution exposure had streaked and banded the statue. In December of that year it was removed from the Loggia and transferred to the Uffizi for cleaning and restoration. It was a slow, years-long process, and the restored statue was not returned to its home until June 2000.






[edit] Decorative art and portraiture


Cellini's Saliera, made in Paris, 1540–1543; Gold, partly covered in enamel, with an ebony base.


Portrait of Cosimo I de Medici, attributed to Cellini's workshop


Cellini's Crucifix at El Escorial Monastery


Clement VII medallionAmong his art works, many of which have perished, were a colossal Mars for a fountain at Fontainebleau and the bronzes of the doorway, coins for the Papal and Florentine states, a life-sized silver Jupiter, and a bronze bust of Bindo Altoviti. The works of decorative art are florid in style.






In addition to the bronze statue of Perseus and the medallions already referred to, the works of art in existence today are a medallion of Clement VII commemorating the peace between the Christian princes, 1530, with a bust of the pope on the reverse and a figure of Peace setting fire to a heap of arms in front of the temple of Janus, signed with the artist's name; a signed portrait medal of Francis; a medal of Cardinal Pietro Bembo; and the celebrated gold, enamel and ivory salt-cellar (known as Saliera) made for Francis I of France at Vienna. This intricate 26-cm-high sculpture, of a value conservatively estimated at 58,000,000 schilling, was commissioned by Francis I. Its principal figures are a naked sea god and a woman sitting opposite each other with legs entwined, symbolically representing the planet Earth. Saliera was stolen from the Kunsthistorisches Museum on 11 May 2003 by a thief who climbed scaffolding and smashed windows to enter the museum. The thief set off the alarms, but these were ignored as false, and the theft remained undiscovered until 8:20 AM. On 21 January 2006 the Saliera was recovered by the Austrian police and is supposed to be returned to the Kunsthistorisches Museum in the coming days. One of the most important works by Cellini from late in his career was a life-size nude crucifix carved from marble. Although originally intended to be placed over his tomb, this crucifix was sold to the Medici family who gave it to Spain. Today the crucifix is in the Escorial Monastery near Madrid, where it has usually been displayed in an altered form—the monastery added a loincloth and a crown of thorns. For detailed information about this work, see the text by Juan López Gajate in the Further Reading section of this article. Cellini, while employed at the papal mint at Rome during the papacy of Clement VII and later of Paul III, created the dies of several coins and medals, some of which still survive at this now defunct mint. He was also in the service of Alessandro de Medici, first duke of Florence, for whom he made in 1535 a forty-soldi piece with a bust of the duke on one side and standing figures of the saints Cosima and Damian on the other. Some connoisseurs attribute to his hand several plaques, "Jupiter crushing the Giants", "Fight between Perseus and Phineus", a Dog, etc. Other works such as the portrait bust shown are not directly attributed but are instead attributed to his workshop.






[edit] Lost worksThe important works which have perished include the uncompleted chalice intended for Clement VII; a gold cover for a prayer book as a gift from Pope Paul III to Charles V, Holy Roman Emperor – both described at length in his autobiography; large silver statues of Jupiter, Vulcan and Mars, wrought for Francis I during his sojourn in Paris; a bust of Julius Caesar; and a silver cup for the cardinal of Ferrara. The magnificent gold "button", or morse (a clasp for a cape), made by Cellini for the cape of Clement VII, the competition for which is so graphically described in his autobiography, appears to have been sacrificed by Pope Pius VI, with many other priceless specimens of the goldsmith's art, in furnishing the 30,000,000 francs demanded by Napoleon I at the conclusion of the campaign against the Papal States in 1797. According to the terms of the treaty, the pope was permitted to pay a third of that sum in plate and jewels. Fortunately there are in the print room of the British Museum three watercolour drawings of this splendid morse by F. Bertoli, done at the instance of an Englishman named Talman in the first half of the 18th century. The obverse and reverse, as well as the rim, are drawn full size, and moreover the morse with the precious stones set therein, including a diamond then considered the second largest in the world, is fully described. Benvenuto's works are mentioned as "priceless" in Mark Twain's The Prince and the Pauper.






[edit] In literature and music[edit] Autobiography and other writingsThe autobiography of Benvenuto Cellini was started in the year 1558 at the age of 58 and ended abruptly just before his last trip to Pisa around the year 1563 when Cellini was approximately 63 years old. The memoirs give a detailed account of his singular career, as well as his loves, hatreds, passions, and delights, written in an energetic, direct, and racy style. They show a great self-regard and self-assertion, sometimes running into extravagances which are impossible to credit. He even writes in a complacent way of how he contemplated his murders before carrying them out. He writes of his time in Paris:






“ When certain decisions of the court were sent me by those lawyers, and I perceived that my cause had been unjustly lost, I had recourse for my defense to a great dagger I carried; for I have always taken pleasure in keeping fine weapons. The first man I attacked was a plaintiff who had sued me; and one evening I wounded him in the legs and arms so severely, taking care, however, not to kill him, that I deprived him of the use of both his legs. Then I sought out the other fellow who had brought the suit, and used him also such wise that he dropped it.[13] ”






Parts of his tale recount some extraordinary events and phenomena; such as his stories of conjuring up a legion of devils in the Colosseum, after one of his not innumerous mistresses had been spirited away from him by her mother; of the marvelous halo of light which he found surrounding his head at dawn and twilight after his Roman imprisonment, and his supernatural visions and angelic protection during that adversity; and of his being poisoned on two separate occasions.






The autobiography has been translated into English by Thomas Roscoe, by John Addington Symonds, and by Anne Macdonell. It has been considered and published as a classic, and commonly regarded as one of the most colourful autobiographies (certainly the most important autobiography from the Renaissance).[14] Cellini also wrote treatises on the goldsmith's art, on sculpture, and on design.

David Foster Wallace (February 21, 1962 – September 12, 2008) was an award-winning American novelist, short story writer, essayist, and professor at Pomona College in Claremont, California. He was widely known for his 1996 novel Infinite Jest.[4][5] In 2005, Time magazine included the novel in its list of the 100 best English-language novels from 1923 to the present.[6]







Los Angeles Times book editor David Ulin called Wallace "one of the most influential and innovative writers of the last 20 years."[4] Wallace's unfinished novel, The Pale King, was published in 2011, and in 2012 was a finalist for the Pulitzer Prize. A biography of Wallace by D. T. Max, titled Every Love Story Is a Ghost Story, will be published in September 2012.[7]


PersonalWallace was born in Ithaca, New York, to James Donald Wallace and Sally Foster Wallace. In his early childhood, Wallace lived in Champaign, Illinois. In fourth grade, he moved to Urbana and attended Yankee Ridge school and Urbana High School. As an adolescent, Wallace was a regionally ranked junior tennis player.







He attended his father's alma mater, Amherst College, and majored in English and philosophy, with a focus on modal logic and mathematics. His philosophy senior thesis on modal logic, titled Richard Taylor's 'Fatalism' and the Semantics of Physical Modality (described in James Ryerson's 2008 New York Times essay "Consider the Philosopher"[8]) was awarded the Gail Kennedy Memorial Prize.[9] His other senior thesis, written for his English major, would later become his first novel.[10] Wallace graduated summa cum laude for both theses in 1985, and in 1987 received a Master of Fine Arts in creative writing from the University of Arizona.






Though he made little mention of it in his writing, Wallace belonged to a church wherever he lived.[11]






[edit] Family


David Foster Wallace alternate dust jacket photo for Infinite JestWallace's father was James D. Wallace, who accepted a teaching job at the University of Illinois at Urbana-Champaign in the fall of 1962 after finishing his graduate course work in philosophy at Cornell University. He received his PhD from Cornell in 1963 and is now Emeritus Professor at Urbana-Champaign. Wallace's mother, Sally Foster Wallace, attended graduate school in English Composition at the University of Illinois and became a professor of English at Parkland College — a community college in Champaign — where she won a national Professor of the Year award in 1996. Wallace's younger sister, Amy Wallace Havens of Tucson, Arizona, has practiced law since 2005.






In the early 1990s, Wallace had a relationship with the poet and memoirist Mary Karr (The Liars' Club). Wallace married painter Karen L. Green on December 27, 2004.[12][13] Dogs played an important role in Wallace's life:[14] He was very close to his two dogs, Bella and Werner;[13] had spoken of opening a dog shelter[14]; and, according to Jonathan Franzen, "had a predilection for dogs who'd been abused, and [were] unlikely to find other owners who were going to be patient enough for them."[13]






[edit] DeathWallace committed suicide by hanging himself on September 12, 2008.[15] In an interview with The New York Times, Wallace's father reported that Wallace had suffered from depression for more than 20 years and that antidepressant medication had allowed him to be productive.[12] When he experienced severe side effects from the medication, Wallace attempted to wean himself from his primary antidepressant, phenelzine.[13] On his doctor's advice, Wallace stopped taking the medication in June 2007,[12] and the depression returned. Wallace received other treatments, including electroconvulsive therapy. When he returned to phenelzine, he found it had lost its effectiveness.[13] In the months before his death, his depression became severe.[12]






Numerous gatherings were held to honor Wallace after his death, including memorial services at Pomona College, Amherst College, University of Arizona, and on October 23, 2008, at NYU — the latter with speakers including his sister, Amy Wallace Havens; his agent, Bonnie Nadell; Gerry Howard, the editor of his first two books; Colin Harrison, editor at Harper's Magazine; Michael Pietsch, the editor of Infinite Jest and Wallace's later work; Deborah Treisman, fiction editor at The New Yorker; as well as authors Don DeLillo, Zadie Smith, George Saunders, Mark Costello, Donald Antrim, and Jonathan Franzen.[16]






[edit] Writing and other media[edit] Career


David Foster Wallace giving a reading for Booksmith at San Francisco's All Saints Church in 2006Wallace's first novel, 1987's The Broom of the System, garnered national attention and critical praise. Caryn James of The New York Times called it a successful "manic, human, flawed extravaganza," "emerging straight from the excessive tradition of Stanley Elkin's Franchiser, Thomas Pynchon's V., John Irving's World According to Garp."[17] Wallace moved to Boston, Massachusetts, for graduate school in philosophy at Harvard University, but soon abandoned it. In 1991 he began teaching literature as an adjunct professor at Emerson College in Boston.






In 1992, at the behest of colleague and supporter Steven Moore, Wallace obtained a position in the English department at Illinois State University. He had begun work on his second novel, Infinite Jest, in 1991, and submitted a draft to his editor in December 1993. After the publication of excerpts throughout 1995, the book was published in 1996.






Wallace published short fiction in Might, GQ, Playboy, The Paris Review, Harper's Magazine, Mid-American Review, Conjunctions, Esquire, Open City, Timothy McSweeney's Quarterly Concern, The New Yorker, and Science.






In 1997, Wallace received a MacArthur Fellowship, as well as the Aga Khan Prize for Fiction, awarded by editors of The Paris Review for one of the stories in Brief Interviews — "Brief Interviews with Hideous Men #6" — which had appeared in the magazine.






In 2002, he moved to Claremont, California, to become the first Roy E. Disney Professor of Creative Writing and Professor of English at Pomona College. He taught one or two undergraduate courses per semester, and focused on his writing.






In May 2005, Wallace delivered the commencement address to the graduating class at Kenyon College. The speech was published as a book in 2009 under the title This Is Water.[18]






Bonnie Nadell was Wallace's literary agent through his entire career.[19] Michael Pietsch was his editor on Infinite Jest.[20]






In March 2009, Little, Brown and Company announced that it would publish the manuscript of an unfinished novel, The Pale King, that Wallace was working on at the time of his death. The Pale King was pieced together by editor Michael Pietsch from pages and notes the author left behind.[21][22] Several excerpts from it were published in the New Yorker and other magazines. The Pale King was published on April 15, 2011, and received generally positive reviews.[23]






In March 2010, it was announced that Wallace's personal papers and archives – drafts of books, stories, essays, poems, letters, and research, including the handwritten notes for Infinite Jest — had been purchased by the University of Texas at Austin and will reside at the University's Harry Ransom Center.[24]






[edit] Themes and stylesWallace's fiction is often concerned with irony. His essay "E Unibus Pluram: Television and U.S. Fiction,"[25] originally published in the small-circulation Review of Contemporary Fiction in 1993, proposes that television has an ironic influence on fiction writing, and urges literary authors to eschew TV's shallow rebelliousness: "I want to convince you that irony, poker-faced silence, and fear of ridicule are distinctive of those features of contemporary U.S. culture (of which cutting-edge fiction is a part) that enjoy any significant relation to the television whose weird pretty hand has my generation by the throat. I'm going to argue that irony and ridicule are entertaining and effective, and that at the same time they are agents of a great despair and stasis in U.S. culture, and that for aspiring fictionists they pose terrifically vexing problems." Wallace used many forms of irony, but focused on individuals' continued longing for earnest, unselfconscious experience and communication in a media-saturated society.[26] Literary critic Adam Kirsch said that Wallace's "self-conscious earnestness" and "hostility to irony defined a literary generation."[27]






Wallace's novels often combine various writing modes or voices, and incorporate jargon and vocabulary (sometimes invented) from a wide variety of fields. His writing featured self-generated abbreviations and acronyms, long multi-clause sentences, and a notable use of explanatory footnotes and endnotes — often nearly as expansive as the text proper. He used endnotes extensively in Infinite Jest and footnotes in "Octet" as well as in the great majority of his nonfiction after 1996. On the Charlie Rose show in 1997, Wallace claimed that the notes were used to disrupt the linearity of the narrative, to reflect his perception of reality without jumbling the entire structure. He suggested that he could have instead jumbled up the sentences, "but then no one would read it."[28]






According to Wallace, "fiction’s about what it is to be a fucking human being," and he expressed a desire to write "morally passionate, passionately moral fiction" that could help readers "become less alone inside."[29] In his Kenyon College commencement address, he describes the human condition of daily crises and chronic disillusionment and warns against solipsism,[30] invoking compassion, mindfulness, and existentialism:[31]






The really important kind of freedom involves attention, and awareness, and discipline, and effort, and being able truly to care about other people and to sacrifice for them, over and over, in myriad petty little unsexy ways, every day.... The only thing that's capital-T True is that you get to decide how you're going to try to see it. You get to consciously decide what has meaning and what doesn't.... The trick is keeping the truth up-front in daily consciousness.


[edit] Nonfiction workWallace covered Senator John McCain's 2000 presidential campaign[32] and the September 11 attacks for Rolling Stone; cruise ships[33] (in what became the title essay of his first nonfiction book), state fairs, and tornadoes for Harper's Magazine; the US Open tournament for TENNIS Magazine; the director David Lynch and the pornography industry for Premiere magazine; the tennis player Michael Joyce for Esquire; the special-effects film industry for Waterstone's magazine; conservative talk radio host John Ziegler for The Atlantic Monthly;[34] and a Maine lobster festival for Gourmet magazine. He also reviewed books in several genres for the Los Angeles Times, The Washington Post, The New York Times, and The Philadelphia Inquirer. In the November 2007 issue of The Atlantic, which commemorated the magazine's 150th anniversary, Wallace was among the authors, artists, politicians and others who wrote short pieces on "the future of the American idea."






[edit] Other mediaTwelve of the interviews from Brief Interviews With Hideous Men were adapted into a stage play in 2000, the first theatrical adaptation of Wallace's work. The play, Hideous Men, adapted and directed by Dylan McCullough, premiered at the New York International Fringe Festival in August 2000.






A filmed adaptation of Brief Interviews, directed by John Krasinski, was released in 2009 and premiered at the Sundance Film Festival.[35] The film stars Julianne Nicholson and an ensemble cast including Christopher Meloni, Rashida Jones, Timothy Hutton, Josh Charles, Will Forte and Corey Stoll.[36]






Brief Interviews was also adapted by director Marc Caellas as a play called Brief Interviews With Hideous Writers, which premiered at Fundación Tomás Eloy Martinez in Buenos Aires on November 4, 2011.[37]






The short story "Tri-Stan: I Sold Sissee Nar to Ecko" from Brief Interviews With Hideous Men was adapted by composer Eric Moe[38] into a 50-minute operatic piece, to be performed with accompanying video projections.[39] The piece was described as having "subversively inscribed classical music into pop culture."[40]






The Simpsons episode "A Totally Fun Thing That Bart Will Never Do Again" (first aired April 29, 2012) is loosely based on Wallace's essay "A Supposedly Fun Thing I'll Never Do Again". The Simpson family takes a cruise, and Wallace appears in the background of a scene, wearing a tuxedo T-shirt while eating in the ship's dining room; Wallace recounts having worn such a T-shirt "at formal suppers".











A esquistossomose, com o desenvolvimento da agricultura, passou de doença rara a problema sério.
Muitas múmias egípcias apresentam as lesões inconfundíveis da esquistossomose por S. haematobium. A infecção pelos parasitas dava-se nos trabalhos de irrigação da agricultura. As cheias do Nilo sempre foram a fonte da prosperidade do Egito, mas também traziam os caracóis portadores dos schistosomas. O hábito dos agricultores de fazer as plantações e trabalhos de irrigação com os pés descalços metidos na água parada, favorecia a disseminação da doença crónica causada por estes parasitas. O povo, cronicamente debilitado pela doença, era facilmente dominável por uma classe de guerreiros que, uma vez que não praticavam a agricultura irrigada, não contraíam a doença, mantendo-se vigorosos. Estas condições permitiram talvez a cobrança de impostos em larga escala com excedentes consideráveis que revertiam para a nova elite de guerreiros, uma estratificação social devida à doença, que se transformaria nas civilizações.[2]
A doença foi descrita cientificamente pela primeira vez em 1851 pelo médico alemão T. Bilharz, que lhe dá o nome alternativo de bilharzíase.

[editar]Progressão e sintomas

A fase de penetração é o nome dado a sintomas que podem ocorrer quando da penetração da cercária na pele, mas mais frequentemente é assintomática, exceto em indivíduos já infectados antes. Nestes casos é comum surgireritema (vermelhidão), reação de sensibilidade com urticária (dermatite cercariana) e prurido e pele avermelhada ou pápulas na pele no local penetrado, que duram alguns dias.
Na fase inicial ou aguda, a disseminação das larvas pelo sangue, e principalmente o início da postura de ovos nas veias que vão para o fígado ativa o sistema Bulateral surgindo Bolinhas de pus, mal estar, cefaléias (dores de cabeça),astenia (fraqueza), dor abdominal, diarreia sanguinolenta, dispnéia (falta de ar), hemoptise (tosse com sangue), artralgias, linfonodomegalia e esplenomegalia, um conjunto de sintomas conhecido por síndrome de Katayama, que geralmente aparece após três a nove semanas após a penetração das cercárias. Nas análises sanguíneas há eosinofilia (aumento dos eosinófilos, células do sistema imunitário antiparasitas). Estes quadros só ocorrem secundariamente à hipersensibilidade ao parasita, sendo uma doença mais comum em pacientes moradores de áreas não endêmicas que se expõem a coleções hídricas contaminadas. Estes quadros duram em geral alguns dias, mas podem durar até meses e em casos raros podem ser fatais. Estes pacientes apresentam grandes granulomas periovulares necrótico-exsudativos dispersos pelos intestinos, fígado e outros órgãos. Estes sintomas podem ceder espontaneamente ou podem nem sequer surgir, mas a doença crônica silenciosa.
Os sintomas crônicos são quase todos devidos à produção de ovos imunogénicos. Estes são destrutivos por si mesmos, com o seus espinhos e enzimas, mas é a inflamação com que o sistema imunitário lhes reage que causa os maiores danos. As formas adultas não são atacadas porque usam moléculas self do próprio hóspede para se camuflar. Os sintomas desta fase crônica podem ser a hepatopatias/enteropatias com hepatomegalia, ascite, diarreia no caso da esquistossomose mansônica, única que existe no Brasil. As formas mais graves com hepatomegalia ehipertensão portal são as principais causas de morte por esquistossomose no Brasil. A esquistossomose hematóbia, que existe em países africanos pode levar a patologias urinárias como disúria/hematúria, nefropatias, cancer da bexiga.
Outras formas de esquistossomose graves são as formas ectópicas cujas mais importantes são neurológicas que pode ser medular, conhecida como mielopatia esquistossomótica ou esquistossomose medular[3], ou cerebral, quando atingem o cérebro, existem também casos de esquistossomose ectópica na pele, pulmão, tuba uterina e outras vísceras.

[editar]O ciclo da Esquistossomose

Esquistossomose-2.png

[editar]Diagnóstico

Os ovos podem ser encontrados no exame parasitológico de fezes, mas nas infecções recentes o exame apresenta baixa sensibilidade. Para aumentar a sensibilidade podem ser usados de coproscopia qualitativa, como Hoffman ou quantitativo, como Kato-Katz. A eficácia com três amostras chega apenas a 75%.
O hemograma demonstra leucopenia, anemia e plaquetopenia. Ocorrem alterações das provas de função hepática, com aumento de TGO, TGP e fosfatase alcalina. Embora crie a hipertensão portal, classicamente a esquistossomose preserva a função hepática. Assim, os critérios de Child-Pught, úteis no cirrótico, nem sempre funcionam no esquistossomótico que não tem associado hepatite viral ou alcoólica.
A ultra-sonografia em mãos experientes pode fazer o diagnóstico, sendo patognomônico a fibrose e espessamento periportal, hipertrofia do lobo hepático esquerdo e aumento do calibre da mesentérica superior.[4]
A biopsia retal é uma técnica também utilizável, tendo uma sensibilidade de 80%.

[editar]Profilaxia

Saneamento básico com esgotos e água tratadas. Erradicação dos caramujos que são hospedeiros intermediários da doença. Proteção dos pés e pernas com botas de borracha com solado antiderrapante. Informar a população das medidas profiláticas da doença. Evitar entrar em contato com água que contenha cercárias.

[editar]Tratamento

O tratamento é feito com antiparasitários (praziquantel ou oxamniquina) para matar o parasita dentro do corpo e dura 1 ou 2 dias.

Ellis researched murders at the New York Public Library. His first draft of American Psycho left all the grisly scenes until last, to be added in later. To one reviewer, Ellis comments:
“[Bateman] was crazy the same way [I was]. He did not come out of me sitting down and wanting to write a grand sweeping indictment of yuppie culture. It initiated because my own isolation and alienation at a point in my life. I was living like Patrick Bateman. I was slipping into a consumerist kind of void that was supposed to give me confidence and make me feel good about myself but just made me feel worse and worse and worse about myself. That is where the tension of "American Psycho" came from. It wasn't that I was going to make up this serial killer on Wall Street. High concept. Fantastic. It came from a much more personal place, and that's something that I've only been admitting in the last year or so. I was so on the defensive because of the reaction to that book that I wasn't able to talk about it on that level.[5]

Synopsis

Set in Manhattan during the Wall Street boom of the late 1980s, American Psycho is about the daily life of wealthy young investment banker Patrick Bateman. Bateman, in his late 20s when the story begins, narrates his everyday activities, from his recreational life among the Wall Street elite of New York to his forays into murder by nightfall. Through present tense stream-of-consciousness narrative, Bateman describes his daily life, ranging from a series of Friday nights spent at nightclubs with his colleagues — where they snort cocaine, critique fellow club-goers' clothing, trade fashion advice, and question one another on proper etiquette — to his loveless engagement to fellow yuppie Evelyn and his contentious relationship with his brother and senile mother. Bateman's stream of consciousness is occasionally broken up by chapters in which he directly addresses the reader in order to critique the work of 1980s Pop music artists. The novel maintains a high level of ambiguity through such devices as mistaken identity, and contradictions which introduce the possibility that Bateman is an unreliable narrator. Characters are consistently introduced as other people, people argue over the identities of others they can see in restaurants or at parties. Whether any of the crimes depicted in the novel actually happened, or were simply the fantasies of a delusional psychotic, is deliberately left open.
Bateman comes from a privileged background; he works as a vice president at a Wall Street investment company and lives in an expensive Manhattan apartment on the Upper West Side, where he embodies the 1980s yuppie culture. As Bateman describes his day-to-day activities, the mundane details become interspersed with descriptions of brutal murders he carries out in secret. After killing one of his colleagues, Paul Owen, one evening, Bateman appropriates his apartment as a place to kill and store more victims. In addition to describing his daily life, Bateman also details his sexual relationships. He is dating a fellow yuppie named Evelyn, though he possesses no deep feelings for her. He frequently solicits sex with attractive women, whom he refers to as "hardbodies." Bateman also documents his interactions with his estranged family, specifically his mother and his brother, Sean Bateman, who is a main character in Ellis's The Rules of Attraction.
Bateman's control over his violent urges deteriorates. The description of his murders become increasingly sadistic and complex, progressing from stabbings to drawn out sequences of torture, rape, mutilation, cannibalism, and necrophilia, and the separation between his two lives begins to blur. He introduces stories about serial killers into casual conversations, and on several occasions openly confesses his murderous activities to his co-workers, who never take him seriously, do not hear what he says, or misunderstand him completely, hearing the words "murders and executions" as "mergers and acquisitions", for example. Bateman begins to experience bizarre hallucinations such as seeing a Cheerio interviewed on a talk show, being stalked by an anthropomorphic park bench, and finding a bone in his Dove Bar. These incidents culminate in a shooting spree during which he kills several random people in the street resulting in a SWAT team being dispatched in a helicopter. Bateman flees on foot and hides in his office, where he phones his attorney, Harold Carnes, and confesses all of his crimes to the answering machine.
Later, Bateman confronts Carnes about the message only to find Carnes is amused at what he considers to be a good joke. Carnes tells Bateman that he is too much of a coward to have committed such acts and claims that he had dinner in London with Paul Owen a few days previously. Bateman re-visits the murdered Paul Owen's apartment, where he had killed and mutilated two prostitutes. Bateman enters the perfectly clean, refurbished apartment which shows no trace of decomposing bodies, but is filled with strong-smelling flowers, as though meant to hide a bad odor. He runs into a real estate agent showing the apartment to prospective buyers, and who appears suspicious of Bateman.
The book ends as it began, with Bateman and his colleagues in a club on a Friday night, engaging in mundane conversation. Bateman comes to the conclusion that he is proud of who he is, but fails when he attempts to articulate why.

[edit]

Christian Bale as Patrick Bateman in the film adaptation.

[edit]Controversy

The book was originally to have been published by Simon & Schuster in March 1991, but the company withdrew from the project because of "aesthetic differences." Vintage Books purchased the rights to the novel and published the book after the customary editing process. The book was never published in hardcover form in the United States, although a deluxe paperback was eventually offered.[7] Ellis received numerous death threats and hate mail after the publication of American Psycho."[8][9]
In Germany, the book was deemed "harmful to minors," and its sales and marketing were severely restricted from 1995 to 2000. In Australia, the book is sold shrink-wrapped and is classified "R18" under national censorship legislation. The book may not be sold to those under 18 years of age, or criminal prosecution may result. Along with other Category 1 publications, its sale is theoretically banned in the state of Queensland and it may only be purchased shrink-wrapped. In Brisbane, the novel is available to those over 18 from all public libraries and can still be ordered and purchased (shrink-wrapped) from many book stores despite this prohibition.[10] Bret Easton Ellis has commented on this, saying "I think it's adorable, I think it's cute, I love it."[11][12] In New Zealand, the Government's Office of Film & Literature Classification has rated the book as R18. The book may not be sold or lent in libraries to those under 18 years of age. It is generally sold shrink wrapped in bookstores. In Canada, the book generated renewed controversy during the trial of serial killer Paul Bernardo after it was discovered that Bernardo owned a copy of the book and had "read it as his 'bible'."[13]
Feminist activist Gloria Steinem was among those opposed to the release of Ellis' book because of its portrayal of violence toward women. Steinem is also the stepmother of Christian Bale, who played Bateman in the film. This coincidence is mentioned in Ellis' mock memoir Lunar Park.